Pancreatic Cancer Research Today is a free monthly online journal that collates and summarizes the latest research about Pancreatic Cancer, including details on symptoms, causes, treatment, information.

The role of protein kinases in pancreatic carcinogenesis.

Ammerpohl O, Kalthoff H

University Hospital of Schlewig-Holstein, Campus Kiel, Clinic for General Surgery and Thoracic Surgery, Division of Molecular Oncology, Arnold-Heller-Strasse 7, 24105 Kiel, Germany.

BACKGROUND: Pancreatic cancer is a devastating disease with a very poor prognosis. METHODS: Protein kinases are aberrantly expressed in pancreatic ductal adenocarcinoma as analyzed by microarray-based expression analysis and have an impact for pancreatic cancer. Many regulatory proteins have an impact on cancer progression similar to the kinases. The list contains several regulators of kinases derived from the cell cycle control or the mitogen-activated protein (MAP)-kinase pathway. CONCLUSION: Both signalling pathways are essential for tumor progression and pancreatic ductal adenocarcinoma (PDAC) malignancy.

Published 15 May 2007 in Clin Chim Acta, 381(1): 56-62.
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