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Extended pancreatectomy with resection of the celiac axis: the modified Appleby operation.

Gagandeep S, Artinyan A, Jabbour N, Mateo R, Matsuoka L, Sher L, Genyk Y, Selby R

Division of Hepatobiliary/Pancreatic Surgery and Transplant Surgery, University of Southern California University Hospital, 1510 San Pablo St., HCC1 Suite 200, Los Angeles, CA 90033, USA.

BACKGROUND: Celiac axis invasion by central and distal pancreatic cancers has been considered a contraindication to resection. Appleby first described en-bloc celiac axis resection with total gastrectomy for locally advanced gastric cancer. We present our experience with a modification of this procedure in central pancreatic cancers involving the celiac trunk. METHODS: Three patients with central pancreatic cancers invading the celiac axis are reviewed. All patients underwent extended pancreatectomy with en-bloc resection of the celiac axis. RESULTS: Margins were grossly clear of tumor in all patients. The mean length of stay was 8.3+/-1.1 days. There was no evidence of clinically significant gastric or hepatic ischemia. All 3 patients remain disease free at 34, 14, and 14 months from surgery, respectively. COMMENTS: Extended pancreatectomy with celiac axis resection can result in prolonged survival and should be considered in central and distal pancreatic cancers invading the celiac trunk.

Published 21 August 2006 in Am J Surg, 192(3): 330-5.
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